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Hematology

ITP Response Assessment (IWG Criteria)

International Working Group criteria for assessing treatment response in Immune Thrombocytopaenia (ITP)

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What is the ITP Response Assessment (IWG Criteria)?

Clinical background · Scoring criteria · Evidence-based pearls

Hematology
Developed by: Francesco Rodeghiero and the International Working Group on ITP (2009)
Validated in: International consensus recommendations; used in all major ITP clinical trials since 2009

The International Working Group (IWG) criteria for ITP response assessment were established by Rodeghiero and colleagues in 2009 to standardise the terminology and outcome definitions used in ITP clinical trials and clinical practice — replacing a confusing patchwork of 14 different response criteria used previously. The 2009 IWG guidelines defined complete remission, response, sustained response, and no response using objective platelet count thresholds and treatment-free periods. Immune Thrombocytopenia (ITP) affects approximately 3-5 per 100,000 adults annually, with clinical manifestations ranging from incidental thrombocytopaenia to life-threatening haemorrhage.

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