Acute kidney injury classification per KDIGO guidelines
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Clinical background · Scoring criteria · Evidence-based pearls
The KDIGO (Kidney Disease: Improving Global Outcomes) AKI staging system was published in 2012 to provide a unified, internationally standardised definition and classification of acute kidney injury. Prior to KDIGO, inconsistent AKI definitions (RIFLE, AKIN) led to challenges in comparing study populations. KDIGO defined AKI as any of: increase in serum creatinine by ≥0.3 mg/dL within 48 hours, increase to ≥1.5× baseline within 7 days, or urine output <0.5 mL/kg/hour for ≥6 hours. Even small creatinine rises (Stage 1) independently predict mortality and hospital length of stay.
Other evidence-based tools commonly used alongside this calculator
eGFR Calculator (NKF Guidelines)
Comprehensive eGFR calculator with CKD staging per National Kidney Foundation
Fractional Excretion of Urea (FEUrea)
Alternative to FENa when on diuretics
Kidney Failure Risk Equation (KFRE)
2-year and 5-year risk of kidney failure (NKF recommended)
Urine Anion Gap
Evaluate renal response in metabolic acidosis
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