The TIMI Risk Score for ST-Elevation Myocardial Infarction (STEMI) was developed by Morrow and colleagues at Brigham and Women's Hospital in 2000, derived from the InTIME II trial of 14,114 STEMI patients treated with fibrinolytic therapy (lanoteplase vs alteplase). It was designed to rapidly stratify 30-day mortality risk in STEMI patients, particularly to identify those who would derive the greatest absolute mortality benefit from aggressive reperfusion therapy. The TIMI STEMI score is a continuous 0-14 point scale using eight variables, all available at the bedside before reperfusion therapy is initiated.